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KMID : 0359920090280050433
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Korean Journal of Nephrology
2009 Volume.28 No. 5 p.433 ~ p.443
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The Relation of Arterial Stiffness with Vascular Calcification and BMD in Chronic Kidney Disease
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Shin Young-Shin
Shin Mi-Jung
Song Ho-Cheol
Kim Dae-Bum
Kim Young-Soo
Kim Byung-Soo
Kim Young-Ok
Kim Yong-Soo
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Abstract
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Purpose:Vascular calcification with arterial stiffness as well as bone mineral density was compared in hemodialysis, peritoneal dialysis patients, and pre-dialysis patients.
Methods:The calcification level of the aorta was scored, the arterial stiffness level was examined by pulse wave velocity (PWV), and bone mineral density was measured by the use of DEXA, and analyzed.
Results:PWV was significantly higher in the calcification group. The systolic blood pressure and the PWV value of the HD group was r=0.566 (p<0.001), the PD group was r=0.711 (p<0.001), and the pre-dialysis patients group was r=0.461 (p=0.001), and in all groups, a high correlation was shown. In the association of the PWV value with BMD and T score, in the PD patient group, with spine BMD, it was r=-0.351 (p<0.05), femur BMD was r=-0.510 (p<0.01), and femur T score was r=-0.527 (p= 0.001). In the multivariate analysis of the PWV value, in the HD group, age and systolic blood pressure were significant and in the PD group, calcification score femur BMD, femur T score, and CRP were significant factors. In the pre-dialysis patients group, only femur T score was detected to be a significant factor for PWV.
Conclusion:In hemodialysis patients, age and systolic blood pressure, and in peritoneal dialysis patients, vascular calcification and the BMD level were analyzed to be significant factors mediating effects on arterial stiffness.
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KEYWORD
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Vascular calcification, Bone mineral density, CKD
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